Elevated Kappa Light Chains But Normal Ratio

Normal values for kappa lambda and flc ratio.

Elevated kappa light chains but normal ratio. These unlinked chains are known as free light chains. Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia. Lambda and kappa light chains. You have a minimal degree of change this may be wi.

What else should i ask answered by dr. In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm. An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65. Once an abnormal free light chain flc k l ratio has been demonstrated and a diagnosis has been made the quantitation of the monoclonal light chain is useful for monitoring disease activity.

The kappa lambda ratio did not correlate with age proteinuria or egfr. Kappa light chain concentration range. 5 7 26 3 mg ml. It is normal for there to be small fluctuations in the uninvolved light chain concentration over time which have no clinical significance at all.

Lambda light chain concentration range. Serum free light chains can also be increased usually with a normal kappa lambda ratio with some connective tissue disorders inflammatory conditions neurological conditions and some cancers but are not typically monitored in. The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65.

There are two types of light chains. The specificity of this assay for detection of monoclonal light chains relies on the ratio of free kappa and lambda k l light chains. Told me my kappa light chain is elevated at 26. A free light chains test measures the amount of lambda and kappa free light chains in the blood.

This balance of kappa and lambda together is called the kappa lambda ratio which can also indicate a change in levels of disease. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells.